The "2 wire" is created by tying Tx+ to RX+ as 1 wire and Tx- to RX- as the other wire. Look up the PLC's requirement for termination resistors. Then try this hookup with the closest "2 wire" instrument. If it works, add on another always moving the other set of termination resistors to the far end of the line. Of course like any other network the Modbus devices will have to be assigned distinct addresses.
Be careful about major differences in the grounding. You may wish to use isolation between the PLC module and the line.
As noted by Jim Dungar the method behind the hardware is not always the same. Though the protocol, Modbus, is defined, its method of implementation could be taking advantage of the seperated transmit and recieve channels which the 4 wire allows. If so it may not like the 2 wire hookup. That is why I suggested trying it just on one unit. I assume you don't have any information on the PLC side requiring one or the other else you wouldn't have to ask.
The instrument you are using, reads from the PLC module or writes to the PLC module? maybe a manual written for the instrument might have stated what it needs and what it does. Sometimes you just need Tx+ and Tx-, or Rx+ and Rx-, or as Bern said, TRx+ and TRx- (jump the positive connections together and same goes for the negatives).
If you jumper the 'like' rx and tx lines on the 4-wire device, the issues you're going to need to watch for are (i) does the 4-wire device turn off its transmitter when not sending? and (ii) does it turn off its receiver when it is sending? If it's a 4-wire master device, it may not meet either of these conditions...