The main challenge is that RIO is a daisy-chain network that requires termination resistors on the end of the cable.
If you put one of the termination resistors on the removable machine, you will have to connect a replacement resistor to the network when you unplug the removable equipment.
There is also a chance that the whole network will fault when you unplug the removable equipment, because one termination resistor will be missing.
RIO is fairly forgiving, but only a physical test will find out for sure.
If this is a system that shuts down while you are removing gear, then it's no problem. If the RIO network has to keep running even though you've unhooked the end of it... maybe a problem.