4 to 20mA is even better, because you can detect broken wires.
In 2-wire mode you simply measure the resistance of the complete circuit: PT100 plus the wiring, connections et cetera. This circuit usually forms a voltagedivider with a fixed resistor inside the measuring system, e.g. an analog inputcard.
PT100 4-wire is better than 2-wire because the effect of the wires is less. It also works in a different way: you send a current through the PT100 using one pair of wires and you measure the voltage drop over the PT100 over the other pair. For the voltage measurement you can use a high impedance measuring circuit, which influences the measuring results in a far smaller way. In some circuits the current sent through the PT100 is fixed, but sometimes it's a modulated signal. By filtering out the desired frequency in the measuring circuit you can eliminate noise.
Kind regards,