This sounds like what happens to me on a regular basis with 5.10. I usually must shut down Factory Talk View and restart it. Sometimes, I must reboot my PC to get the graphics to operate correctly.
My menus will be blank with a black background. Sometimes, I can get the graphics to appear well enough to navigate to the correct menu choice.
This happens with both Machine Edition and Site Edition Local or Distributed.
Now, if you haven't gotten the software to operate correctly at all with this installation, then you may have an issue with .net framework or the factory talk directory services platform.
Even once you get everything correctly installed, be prepared for frequent problems. Some people report no trouble at all with the software, but I have not had such luck.