Many times a common part, like a terminal strip, is used even if there are fewer signals. This prevents a needless variety of parts. You may have noticed the similarity of packages for add-on cards. It would be strange if all used exactly the same number of signals.
It is best if the unused terminals touch no active circuit trace.
But I have seen designs where a no longer used trace lands at the terminal and it would be bad if an incompatible voltage were tied there. The NC could just mean that there is no usable signal there, but it is best to treat it as a command - "THOU SHALT PLACE NO WIRE HERE!"