I have only 2 sets of software that would not install straight into 64 bit and they are the Beijer screen software played up and Modscan would not install and work in 64 bit. I simply put a dual boot on the laptop for those two programs as I do not use them often.
All PLC software, except for Omron CX-One, is installed either in the included XP mode or a Virtual Box. The only reason the Omron software is straight into 64 bit is that it shuts down clean and does not do all the nasty things like hang onto serial ports that most of the others do. It also does not spray sundry files all over the hard drive - it is a really efficient, clean program. It also plays nice with all other software.