As far as I know it will not work with Windows M.E. or newer 2000 or xp. I have an old compaq 486/33 with windows 95 running in DOS mode that it does work on. Yes, the software will run on the Windows M.E. using an older pentium Gateway laptop but it will not communicate. I have a cable I have tested this with to be sure. The cable is a special interface with a chip inside the DB25 connector. It is embedded in epoxy. So far I haven't been able to get the part number off it. I was told that a serial number of some kind is programmed into this chip, but I don't know that for certain. As I understand it the program is burned into a removable EPROM chip (or two EPROM chips) on the CPU board. If you have access to an EPROM copier and burner (programmer) and could send me the copied chip(s), I would be willing install this program chip(s) into a working unit to pull the program off for you and email the printout of the ladder back to you for free. Let me know if I can help.
Sid