If you need a dependable backup solution I recommend Storage Craft. Veeam is also a good choice but can be a bit expensive for what you get.
Storage Craft is a sector-based backup and different from anything else on the market.
It can restore to similar or dissimilar hardware or to the cloud (Amazon, Azure, or Storage Craft) or to a VM in any major virtualization platform including VM Ware, Hyper-V, and Virtual Box, and KVM.
Incremental backups are small and super fast. I do a lot of high-end IT systems design work and I have seen just about every other solution fall over and fail when it was needed most.
The OneXafe Solo is a good choice if you want a ready-to-go appliance or for branch offices, etc.
The key is this solution can restore in seconds without failure with minimal downtime and it's so simple anyone can manage it.