50 feet (15 meters) is the maximum specified length for an RS-232 connection. I've definitely exceeded this by at least double without any major issues. But if you want to go further using serial comms, you should really consider something based on RS-422 or RS-485.
DH-485 has a maximum cable length of 4,000 feet. It also can support up to 32 nodes, and I believe all of the SLC's support it (but may require additional hardware). It might be a better option for you.
If you give more specific information on what you are trying to accomplish, someone here may be able to give you better guidance for your application.