My favourite instruction set used to be the PC20 one (Philips), because it had only 31 different instructions. So the learning curve was very smooth and I knew all instructions in no time at all. Drawbacks were: it was all instruction list, every timer and counter had to be constructed out of those basic instructions, every program had to be drawn up on beforehand on the drawing board otherwise you couldn't follow any structure at all....
Nowadays I use primarily Simatic S7-300, Simatic S5, Allen-Bradley SLC5/03 and Allen-Bradley CompactLogix. Although these instructions sets are much larger, I do prefer these. Primarily because you can program them in ladder, which makes everything much clearer, even for non-trained maintenance people.
Bottom line: I prefer the ones I already know, because I'm used to them.
Kind regards,