So it is an Instance DB, that is a DB linked to a FB at the FB call.
What do you want to edit, the contents or the structure?
If you want to edit the contents, then this can be done in a VAT table, but the program can overwrite if those bytes are written to.
If you want to edit the structure, then this can only be done within the FB by altering the IN/IN_OUT/OUT/STAT areas, which would then mean you would have to update the calls.