Some of the parameters cannot be edited while in use. Some require the drive to be stopped. Others require the drive to be not enabled. One more: If you change the Input Mode, you must cycle power to the drive or apply a special separate parameter in order for the drive to accept the change.
Also, be sure you have entered the menu structure under Program mode and not Monitor...assuming you are dealing with a drive mounted Human Interface Module.
All the above is from memory so I may be missing other possibilities.