As far as I am aware, you just have to select the PLC in the project tree, then click the download button. Someone correct me if I'm wrong.
Usually, if I make a configuration change with like the HSC instruction, I'll make the change, save the project, compile the project (I don't always do this step but it seems to prevent some problems), click the PLC, then click the download button.
Follow the prompts on the download windows, If it gives you the option to delete all or replace all, select it.