The only time I find multilevel blocks of value is when the bottom row(s) are tied together as power and/or common and the top blocks are the input or output signals. Trying to use each level of each row as a unique wire makes field work a cussing fit...Only use them if you have dozens of sensors and they all connect to the bottom rows for power and power supply common and the top row for input signals or some equivalent good cause. Otherwise avoid them and put spares and as much space as you can between terminals and the ducts.
I don't foresee any problems with your signal routing or noise. It is good to be concerned with it, and you understand good wiring practices. It appears you did a fairly decent job of designing to avoid problems within your constraints of keeping the same enclosure and cable entry. I assume that is the reason for the odd location of the main cb/disconnect.
I tend to agree with Jesper you could shuffle them in Autocad or even as "paper dolls" and improve it.
The constraints I am faced with for this are: potential high temperature locations, mounted outdoors, and mounting is configured only for a 42x36 panel without major external component reconfiguration and fabrication - it's a retrofit. The only place the supply power can enter the enclosure is on the top right side. With it being an outdoor location, I didn't want to bring power in through the top, leaving the upper right side for the main breaker/disconnect components.
You can come in at the same point (top right) and easily bend and go straight down into the top of the MCB mounted upright, out of the bottom of it into your main power distribution blocks, if used, or to your main CBs. Are those all 75amp? Or 75amp frames? Anyway from there to your power devices, keep the 3 phase all on the right except for perhaps the supply wires to the low voltage transformer/dc supply.
Paper dolls: Print out the blocks of each object in your panel and a blank sheet of the panel backplate with the stuff that can't be moved printed on it. It can be scaled down for bigger panels or machinery layouts. Rearranging the cut out pieces of paper on a table is often more intuitive and faster and can give your brain a CRT break...
This panel is just busy enough I would tend to have a good plan going in. If it was just a bit simpler, I would go along with a "build it first and then design it" approach like Jesper said. You know all the components you must have, toss in a few you think you might need, and get them ordered asap. lay out the panel and major pieces first with high voltage segregation and wire routing in mind, then order whatever size and depth ducts and extra terminals or spare pieces you might need. Laying it all out in real life with real parts is for sure the best thing to do if you have most of the stuff on hand. Then you can see things you have not consider like for example the depth of the terminal points of some devices from the backplate which call for taller ducts.
At some point you need to ensure the wiring diagram can be accommodated by the number of terminal blocks you have. I really despise seeing terminals stuffed with too many wires especially in a new installation and with modern miniature everything available, there is no excuse.
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