I have the Dymo 5200 and the 3M PL200 which are the same exact Printer. The 2 complaints I have ever had with the Dymo is
1)they don't offer pre-cut shrink tube. Which makes it very hard to pre print your labels and install them as you need. I usually have to either pre print them on the shrink tube and not cut them. Then cut them in the field as you install them. That takes more time and is easier to loose. With the pre cut labels you can print them out and then just tape them to the panel. You can pull them one at a time as you need them.
2) as mentioned earlier there is some waist on the label stock. The shrink tube is always longer than you need. There is no good way to make that margin smaller. I think there may be a profit motive there
I haven't had much issues with the cartridges not working. That has happened maybe once or twice.
Overall I have been happy with my Dymo printers. If they offered the pre cut shrink tube I wouldn't be changing.