I run v19 on Windows 10 without issue, however the official Rockwell response will be to run it in a Windows 7 virtual machine using VMware.
RS5000 Version 20.05 is supported on Windows 10 so it runs natively. Otherwise I use Oracle's VM Virtualbox. It's free and works really well, haven't run into a problem with it yet.
We had similar issue. V19 is NOT officially supported on Windows 10. Sometime it runs but not other time. We ended up upgrading all firmware to V20.
Just because someone here say it runs fine on Win 10 doesn't really help you as again, it's just not officially supported on that OS.